Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma

被引：9

作者：

García, I

Vizoso, F

Suárez, C

Sanz, L

Rodríguez, JC

Roiz, C

García-Muñiz, JL

机构：

[1] Hosp Jove, Serv Cirugia Gen, Gijon 33290, Spain

[2] Hosp Cent Asturias, Serv Cirugia Gen, Oviedo, Spain

[3] Hosp Cent Asturias, Nucl Med Serv, Oviedo, Spain

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2000年 / 15卷 / 03期

关键词：

gastric cancer; histological type; hyaluronic acid; cathepsin D;

D O I：

10.1177/172460080001500302

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this work was to evaluate the cytosolic contents of hyaluronic acid (HA) and cathepsin D (CatD) in gastric carcinomas and their possible relationships with the clinicopathological parameters of the tumors. Our study demonstrated a wide variability in the cytosolic levels of HA (mean +/- SEM: 3748 +/- 411 ng/mg protein) and cathepsin D (52 +/- 4 pmol/mg protein) in the tumors of 78 gastric cancer patients. In addition, the tumoral contents of HA and CatD were significantly higher (p<0.005) in diffuse type (HA: 6027 +/- 1099 ng/mg protein; CatD: 75 +/- 13 pmol/mg protein) than in intestinal type (HA: 2735 +/- 242 ng/mg protein; CatD: 42+/-3 pmol/mg protein) carcinomas. These data suggest that both markers may contribute to the biological characterization of gastric carcinomas.

引用

页码：215 / 218

页数：4