No stirring necessary: Parallel carbonylation of aryl halides with CO and various alcohols under pressure

被引：35

作者：

Blaser, HU

Diggelmann, M

Meier, H

Naud, F

Scheppach, E

Schnyder, A

Studer, M

机构：

[1] Solvias AG, CH-4002 Basel, Switzerland

[2] Syngenta AG, CH-4002 Basel, Switzerland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 09期

关键词：

D O I：

10.1021/jo034112v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The parallel carbonylation of aryl halides with 6-25 bar of CO in 1-mL vials in a standard autoclave was investigated. 4-Bromoacetophenone and 2-chloropyridine were used as model substrates with 102 different O-nucleophiles (primary and secondary alcohols, phenols). No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functions were usually tolerated. The new method is suitable for screening and small scale products synthesis.

引用

页码：3725 / 3728

页数：4

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