A brief history of the contribution of metalloporphyrin models to cytochrome P450 chemistry and oxidation catalysis

被引:209
作者
Mansuy, Daniel [1 ]
机构
[1] Univ Paris 05, UMR 8601, F-75270 Paris 06, France
关键词
hemeproteins; bioniorganic chemistry; drug metabolism; biomimetic systems; dioxygen; iron porphyrins; PORPHYRIN DEPENDENT OXIDATION; CARBON-MONOXIDE-BINDING; IRON-NITROGEN BOND; CRYSTAL-STRUCTURE; LIVER-MICROSOMES; BIOMIMETIC OXIDATION; METABOLIC OXIDATION; DRUG-METABOLISM; NITRIC-OXIDE; FERROTETRAPHENYLPORPHYRIN COMPLEXES;
D O I
10.1016/j.crci.2006.11.001
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Since their discovery in the 1960s, cytochrome P450-dependent monooxygenases have very much attracted the interest of chemists because of their ability to catalyze the selective transfer of an oxygen atom from O-2 to very diverse substrates including alkanes. The huge number of studies performed during these last 30 years on P450s themselves and on iron porphyrin models has led to a detailed understanding of the oxidations catalyzed by iron porphyrins and hemeproteins in general, and to the design of many bioinspired oxidation catalysts. This article gives an overview of what were the main contributions of metalloporphyrin model studies to the fields of P450 chemistry and oxidation catalysis, through a brief comparative history of the development of our knowledge on cytochrome P450 and on the development and use of metalloporphyrin models.
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页码:392 / 413
页数:22
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