Estradiol augments peri-infarct cerebral vascular density in experimental stroke

被引：19

作者：

Ardelt, Agnieszka A.

Anjum, Naseem

Rajneesh, Kiran F.

Kulesza, Piotr

Koehler, Raymond C.

机构：

[1] Univ Alabama, Dept Neurol, Comprehens Stroke Ctr, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

[3] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21218 USA

来源：

EXPERIMENTAL NEUROLOGY | 2007年 / 206卷 / 01期

关键词：

estradiol; angiogenesis; stroke; infarct; penumbra; rat;

D O I：

10.1016/j.expneurol.2007.04.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine poststroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation. (C)) 2007 Elsevier Inc. All rights reserved.

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收藏

页码：95 / 100

页数：6

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