Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve

被引：73

作者：

George, A ^{[1
]}

Buehl, A ^{[1
]}

Sommer, C ^{[1
]}

机构：

[1] Univ Wurzburg, Neurol Klin, D-97080 Wurzburg, Germany

来源：

EXPERIMENTAL NEUROLOGY | 2005年 / 192卷 / 01期

关键词：

peripheral nerve injury; axonal damage; cytokines; nerve de- and regeneration; neuropathic pain;

D O I：

10.1016/j.expneurol.2004.11.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) is involved in injury-induced peripheral nerve pathology and in the generation of neuropathic pain. Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilateral crush or chronic constriction injury (CCI) of mouse sciatic nerves using enzyme-linked immunoassay. Both receptors were detectable at a low level in nerve homogenates from naive mice. After crush or CCI, TNFR1 increased by 2-fold on days 3 and day 7. Unlike TNFR1, TNFR2 was markedly upregulated already on day 1 after crush or CCI. TNFR2 increased by 7-fold on days 3 and 7, and remained elevated at a lower level until day 28 after both CCI and crush injury. These data indicate that endoneurial TNFR1 and TNFR2 proteins are differentially regulated during Wallerian degeneration. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：163 / 166

页数：4

共 25 条

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