The genotype of human transcription factor AP-2β is associated with platelet monoamine oxidase B activity

被引:31
作者
Damberg, M
Garpenstrand, H
Berggård, C
Åsberg, M
Hallman, J
Oreland, L [1 ]
机构
[1] Uppsala Univ, Dept Neurosci, Pharmacol Unit, Uppsala, Sweden
[2] Karolinska Hosp, Dept Clin Neurosci, Unit Psychiat, Karolinska, Sweden
[3] Uppsala Univ, Dept Neurosci, Unit Psychiat, Uppsala, Sweden
关键词
personality; psychiatry; transcription; anxiety; aggression; 5-HT; polymorphism; gene expression;
D O I
10.1016/S0304-3940(00)01405-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Platelet monoamine oxidase B (MAO; EC 1.4.3.4.) activity is stable in the individual and is mainly genetically regulated. Levels of MAO-B in platelets have repeatedly been shown to be associated with personality traits. We have recently also demonstrated an association between the genotype of AP-2 beta to a variety of personality traits as well as binge-eating disorder. In the present study we have analysed blood samples from 158 males and 64 females with regard to platelet MAO activity and genotype of transcription factor AP-SP. In both sexes homozygotes for the long allele [CAAA](5) were significantly associated with low platelet MAO activity P < 0.0001 (males) and P = 0.0158 (females). This study represents a novel approach to increase the understanding about the molecular mechanisms for how the MAOB gene is regulated in blood cells and how this regulation is linked to personality traits. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:204 / 206
页数:3
相关论文
共 21 条
[1]  
[Anonymous], MONOAMINE OXIDASE BA
[2]   A polymorphic region in the human transcription factor AP-2β gene is associated with specific personality traits [J].
Damberg, M ;
Garpenstrand, H ;
Alfredsson, J ;
Ekblom, J ;
Forslund, K ;
Rylander, G ;
Oreland, L .
MOLECULAR PSYCHIATRY, 2000, 5 (02) :220-224
[3]   Transcription factor binding to the core promoter of the human monamine oxidase B gene in the cerebral cortex and in blood cells [J].
Ekblom, J ;
Garpenstrand, H ;
Damberg, M ;
Chen, K ;
Shih, JC ;
Oreland, L .
NEUROSCIENCE LETTERS, 1998, 258 (02) :101-104
[4]   Platelet monoamine oxidase activity is related to MAOB intron 13 genotype [J].
Garpenstrand, H ;
Ekblom, J ;
Forslund, K ;
Rylander, G ;
Oreland, L .
JOURNAL OF NEURAL TRANSMISSION, 2000, 107 (05) :523-530
[5]   DINUCLEOTIDE REPEAT (TG)(23) POLYMORPHISM IN THE MAOB GENE [J].
GRIMSBY, J ;
CHEN, K ;
DEVOR, EJ ;
CLONINGER, CR ;
SHIH, JC .
NUCLEIC ACIDS RESEARCH, 1992, 20 (04) :924-924
[6]   THROMBOCYTE MONOAMINE-OXIDASE ACTIVITY AND PERSONALITY-TRAITS IN WOMEN WITH SEVERE PREMENSTRUAL-SYNDROME [J].
HALLMAN, J ;
ORELAND, L ;
EDMAN, G ;
SCHALLING, D .
ACTA PSYCHIATRICA SCANDINAVICA, 1987, 76 (03) :225-234
[7]  
HARTMANN J, 1993, ACTA NEUROL SCAND, V87, P18
[8]   HIGHLY POLYMORPHIC (GT)N REPEAT SEQUENCE IN INTRON-II OF THE HUMAN MAOB GENE [J].
KONRADI, C ;
OZELIUS, L ;
BREAKEFIELD, XO .
GENOMICS, 1992, 12 (01) :176-177
[9]   TRANSCRIPTION FACTOR AP-2 IS EXPRESSED IN NEURAL CREST CELL LINEAGES DURING MOUSE EMBRYOGENESIS [J].
MITCHELL, PJ ;
TIMMONS, PM ;
HEBERT, JM ;
RIGBY, PWJ ;
TJIAN, R .
GENES & DEVELOPMENT, 1991, 5 (01) :105-119
[10]   Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2 beta [J].
Moser, M ;
Pscherer, A ;
Roth, C ;
Becker, J ;
Mucher, G ;
Zerres, K ;
Dixkens, C ;
Weis, J ;
GuayWoodford, L ;
Buettner, R ;
Fassler, R .
GENES & DEVELOPMENT, 1997, 11 (15) :1938-1948