The genotype of human transcription factor AP-2β is associated with platelet monoamine oxidase B activity

Platelet monoamine oxidase B (MAO; EC 1.4.3.4.) activity is stable in the individual and is mainly genetically regulated. Levels of MAO-B in platelets have repeatedly been shown to be associated with personality traits. We have recently also demonstrated an association between the genotype of AP-2 beta to a variety of personality traits as well as binge-eating disorder. In the present study we have analysed blood samples from 158 males and 64 females with regard to platelet MAO activity and genotype of transcription factor AP-SP. In both sexes homozygotes for the long allele [CAAA](5) were significantly associated with low platelet MAO activity P < 0.0001 (males) and P = 0.0158 (females). This study represents a novel approach to increase the understanding about the molecular mechanisms for how the MAOB gene is regulated in blood cells and how this regulation is linked to personality traits. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.