New Insights into mTOR Signaling: mTORC2 and Beyond

被引：155

作者：

Alessi, Dario R. ^{[1
]}

Pearce, Laura R. ^{[1
]}

Garcia-Martinez, Juan M. ^{[1
]}

机构：

[1] Univ Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci, Dundee DD1 5EH, Scotland

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 67期

基金：

英国医学研究理事会;

关键词：

TURN MOTIF PHOSPHORYLATION; PROTEIN-KINASE-C; P70; S6; KINASE; CAENORHABDITIS-ELEGANS; MAMMALIAN TARGET; BINDING PARTNER; RAG GTPASES; RAPTOR; COMPLEX; RICTOR;

D O I：

10.1126/scisignal.267pe27

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

引用

页数：4

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