A four-step synthesis of erythro-m-chloro-3-hydroxytyrosine ethyl ester enantiomerically pure.

被引：22

作者：

Solladié-Cavallo, A ^{[1
]}

Nsenda, T ^{[1
]}

机构：

[1] Univ Strasbourg 1, ECPM, CNR, Lab Stereochim Organomet, F-67008 Strasbourg, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00172-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pure erythro-m-chloro-3-hydroxytyrosine having the (2R,3R)) configuration, a residue of Vancomycin and Aridicin A, has been prepared in 4 steps using an aldol addition involving a directly generated titanium enolate derived from a chiral iminoglycinate. (+)-Hydroxypinanone was used as a recoverable chiral auxiliary. The (2S,3S)-erythro isomer will be, of course, available from (-)-hydroxypinanone. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2191 / 2194

页数：4

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