Biotechnological production of spider-silk proteins enables new applications

被引：178

作者：

Vendrely, Charlotte ^{[1
]}

Scheibel, Thomas ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Chem, Lehrstuhl Biotechnol, D-85747 Garching, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2007年 / 7卷 / 04期

关键词：

biomaterials; biotechnology; protein engineering; recombinant spider silk;

D O I：

10.1002/mabi.200600255

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The outstanding mechanical properties of spider silks have motivated many researchers to establish biotechnological production techniques which are necessary to provide sufficient amounts of silk proteins for industrial applications. Based on recent developments in genetic engineering, two strategies for the recombinant production of spider-silk proteins have been established which are discussed in detail. Further, protein-design strategies are described, enabling the combination of silk properties with additional biological, chemical, or technical features. We highlight the potential of engineered and recombinantly-produced spider-silk proteins to provide the basis for a new generation of biomaterials.

引用

页码：401 / 409

页数：9

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