Eco-friendly microwave-assisted protocol to prepare hyaluronan-fatty acid conjugates and to induce their self-assembly process

被引：19

作者：

Calce, Enrica ^{[1
]}

Mercurio, Flavia Anna ^{[1
]}

Leone, Marilisa ^{[1
]}

Saviano, Michele ^{[2
]}

De Luca, Stefania ^{[1
]}

机构：

[1] CNR, Inst Biostruct & Bioimaging, I-80138 Naples, Italy

[2] CNR, Inst Crystallog, I-70126 Bari, Italy

来源：

CARBOHYDRATE POLYMERS | 2016年 / 143卷

关键词：

Hyaluronan-based material; Renewable sources; Microwave activation; Solvent-free synthesis; Nanoparticle preparation; Biocompatible process; TARGETED DELIVERY; ORGANIC-SYNTHESIS; NANOPARTICLES; DOCETAXEL; CHEMISTRY; CANCER; CELLS;

D O I：

10.1016/j.carbpol.2016.02.001

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

An environmentally sustainable and energy-efficient synthetic process has been developed to prepare hyaluronan-based nano-sized material. It consists in a microwave-promoted acylation of the hydroxyl function of the polysaccharide with natural fatty acids, performed under solvent-free conditions. The efficient interaction of the solid reagents with the MW radiation accounts for the obtained high yielded products. The self-assembly process of the obtained compounds very fast occurred in an aqueous medium under MW-radiation, thus allowing the development of a green protocol for the nano-particles preparation. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：84 / 89

页数：6

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