The Role of Topiramate and Other Anticonvulsants in the Treatment of Alcohol Dependence: A Clinical Review

被引：19

作者：

De Sousa, Avinash ^{[1
]}

机构：

[1] Carmel, Bombay 400054, Maharashtra, India

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2010年 / 9卷 / 01期

关键词：

Topiramate; alcohol dependence; anticonvulsants; QUALITY-OF-LIFE; DOUBLE-BLIND; WITHDRAWAL SYNDROME; DIVALPROEX SODIUM; LOCUS-COERULEUS; ORAL TOPIRAMATE; ELEVATED LEVELS; NEURONS; LEVETIRACETAM; CARBAMAZEPINE;

D O I：

10.2174/187152710790966696

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Alcohol dependence is a major health problem worldwide. Various pharmacological agents have been used in the management of alcohol dependence. This review looks at the role of topiramate and other anticonvulsants in the management of alcohol dependence. Topiramate is the most widely used anticonvulsant in the treatment of alcohol dependence. The literature on topiramate is reviewed and critically analyzed, along with its proposed mechanism of action in alcohol dependence. A review of data available on other anticonvulsants like carbamazepine, oxcarbazepine, sodium valproate, gabapentin and levetiracetam are presented and their potential in the treatment of alcohol dependence is considered, together with future research directions.

引用

页码：45 / 49

页数：5

共 72 条

[1]

Efficacy of a Combination of Flumazenil and Gabapentin in the Treatment of Alcohol Dependence Relationship to Alcohol Withdrawal Symptoms [J].