HIV vaccines - Viral envelope fails to deliver?

被引：21

作者：

Bolognesi, DP ^{[1
]}

Matthews, TJ ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

来源：

NATURE | 1998年 / 391卷 / 6668期

关键词：

D O I：

10.1038/35504

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Clinical trials of vaccines against the human immunodeficiency virus are underway, but initial results do not seem promising — at least for one type of vaccine. By injecting patients with a recombinant form of a viral envelope protein, gp120, the idea was to induce an antibody response that could fight subsequent infection with the virus. But in a trial of 18 people, all became infected with HIV-1 and, at the level of the immune system, those who had received the vaccine did not seem to deal with the infection any differently than unvaccinated patients.

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页码：638 / 639

页数：2

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