Structure-activity relationships of novel anti-malarial agents.: Part 6:: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

被引：15

作者：

Wiesner, J

Fucik, K

Kettler, K

Sakowski, J

Ortmann, R

Jomaa, H

Schlitzer, M

机构：

[1] Univ Munich, Dept Pharm, Zentrum Pharmaforsch, D-81377 Munich, Germany

[2] Univ Giessen Klinikum, Inst Biochem, D-35249 Giessen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(03)00179-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have demonstrated that the p-trifluoromethylphenylpropionylamino residue at the 2-position of the core structure leads to an active benzophenone-type anti-malarial agent. The attempt to improve water solubility by introduction of an amino group into the alpha-position of the arylpropionyl residue resulted in decreased activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1539 / 1541

页数：3

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