Chronobiology of Plasmodium chabaudi chabaudi: analysis of hourly recorded total and differential parasitaemia during a schizogonic cycle

被引:8
作者
Chimanuka, B [1 ]
Francois, G
Timperman, G
Vanden Driessche, T
Plaizier-Vercammen, J
机构
[1] Free Univ Brussels, Fac Geneeskunde & Farm, Laarbeeklaan 103, B-1090 Jette, Belgium
[2] Inst Trop Med Prince Leopold, B-2000 Antwerp, Belgium
[3] Free Univ Brussels, Dept Biol Mol, B-1640 Rhode St Genese, Belgium
[4] Ctr Rech Sci Nat, Lab Entomol & Parasitol Med, DS Bukavu, Kivu, DEM REP CONGO
关键词
malaria; Plasmodium chaboudi chaboudi; chronobiology; parasitaemia curves; schizogonic cycle;
D O I
10.1051/parasite/1997044319
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Detailed total and differential parasitaemia curves of asexual plasmodium chabaudi chabaudi erythrocytic stages were recorded and analysed. Female, inbred, CBA/Ca mice were infected with the virulent IP-PC1 strain after in vitro synchronization of the parasites. Thin blood smears were made on an hourly basis. and the total and differential parasitaemio of ring forms. trophozoites and schizonts were counted after Giemsa staining. These curves reveal information that remains hidden when less detailed curves are examined: the duration and periodicity of the schizogonic cycle, the existence of a plateau, indications of a schizont withdrawal from the peripheral blood, the timing of the rise of the parasitaemia at each schizogony, and the invasion rate of the merozoites. In the perspective of developing a rational and efficient strategy far chronotherapy of malaria, such information should be taken into account.
引用
收藏
页码:319 / 323
页数:5
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