Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats

被引：63

作者：

Corsi, C ^{[1
]}

Melani, A ^{[1
]}

Bianchi, L ^{[1
]}

Pedata, F ^{[1
]}

机构：

[1] Univ Florence, Dept Preclin & Clin Pharmacol, I-50139 Florence, Italy

来源：

NEUROREPORT | 2000年 / 11卷 / 11期

关键词：

A(2A) adenosine receptor; ageing; glutamate; microdialysis; striatum;

D O I：

10.1097/00001756-200008030-00048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the adenosine A(2A) receptor antagonist SCH 58261 on glutamate release was investigated in the striatum of young and old rats by microdialysis experiments. SCH 58261 (50 nM) significantly decreased the spontaneous and K+-evoked glutamate outflow in young rats. In aged rats, spontaneous glutamate outflow was significantly reduced in comparison to young rats and SCH 58261 significantly increased spontaneous and K+-evoked glutamate outflow. It is suggested that the opposite effects of the A(2A) antagonist on glutamate outflow in young and aged rats can be respectively attributed to blockade of striatal A(2A) adenosine receptors located on glutamatergic terminals and on the striatal indirect output pathway. NeuroReport 11:2591-2595 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：2591 / 2595

页数：5

共 26 条

[1] ADENOSINE A2A-RECEPTORS IN THE NUCLEUS-ACCUMBENS MEDIATE LOCOMOTOR DEPRESSION [J].

BARRACO, RA ;

MARTENS, KA ;

PARIZON, M ;

NORMILE, HJ .

BRAIN RESEARCH BULLETIN, 1993, 31 (3-4) :397-404

[2] Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and 4-aminobutyric acid during microdialysis and from superfused brain slices [J].

Bianchi, L ;

Della Corte, L ;

Tipton, KF .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1999, 723 (1-2) :47-59

[3] Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats [J].

Corsi, C ;

Melani, A ;

Bianchi, L ;

Pepeu, G ;

Pedata, F .

NEUROREPORT, 1999, 10 (04) :687-691

[4] Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo [J].

Corsi, C ;

Melani, A ;

Bianchi, L ;

Pepeu, G ;

Pedata, F .

NEUROREPORT, 1999, 10 (18) :3933-3937

[5] In vivo amino acid release from the striatum of aging rats: Adenosine modulation [J].

Corsi, C ;

Pazzagli, M ;

Bianchi, L ;

DellaCorte, L ;

Pepeu, G ;

Pedata, F .

NEUROBIOLOGY OF AGING, 1997, 18 (02) :243-250

[6] Evidence for high affinity binding sites for the adenosine A(2A) receptor agonist [H-3] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A(2A) receptors [J].

Cunha, RA ;

Johansson, B ;

Constantino, MD ;

Sebastiao, AM ;

Fredholm, BB .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1996, 353 (03) :261-271

[7] Tissue distribution of adenosine receptor mRNAs in the rat [J].

Dixon, AK ;

Gubitz, AK ;

Sirinathsinghji, DJS ;

Richardson, PJ ;

Freeman, TC .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (06) :1461-1468

[8] STIMULATION OF HIGH-AFFINITY ADENOSINE-A2 RECEPTORS DECREASES THE AFFINITY OF DOPAMINE D2 RECEPTORS IN RAT STRIATAL MEMBRANES [J].

FERRE, S ;

VONEULER, G ;

JOHANSSON, B ;

FREDHOLM, BB ;

FUXE, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7238-7241

[9] MOLECULAR-CLONING OF THE RAT ADENOSINE-A2 RECEPTOR - SELECTIVE COEXPRESSION WITH D2-DOPAMINE RECEPTORS IN RAT STRIATUM [J].

FINK, JS ;

WEAVER, DR ;

RIVKEES, SA ;

PETERFREUND, RA ;

POLLACK, AE ;

ADLER, EM ;

REPPERT, SM .

MOLECULAR BRAIN RESEARCH, 1992, 14 (03) :186-195

[10]

FREDHOLM BB, 1994, PHARMACOL REV, V46, P143

← 1 2 3 →