Palladium-Catalyzed Cross-Coupling of Internal Alkenes with Terminal Alkenes to Functionalized 1,3-Butadienes Using C-H Bond Activation: Efficient Synthesis of Bicyclic Pyridones

被引：168

作者：

Yu, Haifeng ^{[1
,2
]}

Jin, Weiwei ^{[1
]}

Sun, Chenglin ^{[1
]}

Chen, Jiping ^{[1
]}

Du, Wangmin ^{[1
]}

He, Songbo ^{[1
]}

Yu, Zhengkun ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Anshan Normal Univ, Dept Chem, Anshan 114007, Liaoning, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 33期

基金：

中国博士后科学基金;

关键词：

alkenes; alkenylation; C-H activation; heterocycles; palladium; PD(II)-CATALYZED OLEFINATION; DIRECT ALKENYLATION; DIRECT ARYLATION; REACTIVITY; ACRYLATES; INDOLES;

D O I：

10.1002/anie.201002737

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

chemical equation presented A highly regioselective direct cross-coupling of internal alkenes of a-oxoketene dithioacetals with terminal alkenes has been successfully realized by palladiumcatalyzed C-H bond activation, affording functionalized 1,3-butadienes. Condensation of the resultant 1,3-butadienes by diamines efficiently produced potentially bioactive bicyclic pyridone derivatives (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5792 / 5797

页数：6

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