Enantiospecific enzymatic synthesis of N-carbamoyl-D-p-fluorophenylglycine and N-carbamoyl-D-p-trifluoromethylphenylglycine

被引：16

作者：

Arcuri, MB

Sabino, SJ

Antunes, OAC

Oestreicher, EG

机构：

[1] Univ Brasil, Inst Quim, BR-21945970 Rio De Janeiro, Brazil

[2] Univ Brasil, Inst Quim, BR-21945970 Rio De Janeiro, Brazil

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2003年 / 121卷 / 01期

关键词：

beta-lactam antibiotics; D-phenylglycine; enantiospecific;

D O I：

10.1016/S0022-1139(02)00335-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiospecific enzymatic hydrolysis of rac-5-arylhydantoins is described. Immobilized D-hydantoinase from Vigna angularis was used to produce with 100% conversion and over 98% enantiomeric excess N-carbamoyl-D-p-fluorophenylglycine and N-carbamoyl-D-p-trifluoromethylphenylglycine. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：55 / 56

页数：2

共 23 条

[1]

ALIG L, 2002, Patent No. 2002004608

[2]

ALIG L, 2002, Patent No. 200181774

[3]

ALIG L, 2002, Patent No. 2001190051

[4]

ALLEGRETTI M, 2001, Patent No. 200146539