Effect of noradrenergic denervation of the amygdala upon recovery after sleep deprivation in the rat

被引：13

作者：

Charifi, C ^{[1
]}

Paut-Pagano, L ^{[1
]}

Debilly, G ^{[1
]}

Cespuglio, R ^{[1
]}

Jouvet, M ^{[1
]}

Valatx, JL ^{[1
]}

机构：

[1] Univ Lyon 1, INSERM, U480, Dept Expt Med, F-69373 Lyon 08, France

来源：

NEUROSCIENCE LETTERS | 2000年 / 287卷 / 01期

关键词：

locus coeruleus; central nucleus of the amygdala; sleep deprivation; water tank technique; rat; N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine; paradoxical sleep; slow wave sleep;

D O I：

10.1016/S0304-3940(00)01106-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We previously showed that the noradrenergic locus coeruleus (NA-LC) was involved in the regulatory mechanisms of the paradoxical sleep rebound following a 10 h sleep deprivation by using a systemic injection of a specific neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4). Given that rebound mechanisms are mainly located in the forebrain, we planned to study the role of the forebrain structures receiving LC afferences. In this study we evaluated the involvement of noradrenergic afferences to the central nucleus of the amygdala in the sleep rebound by DSP-4 microinjections into the central nucleus of the rat amygdala. The results showed that during the first recovery day, the paradoxical sleep rebound is lower in DSP-4 treated rats (-67.28%). These findings indicate that the amygdala, through its NA afferents, contributes to the sleep rebound mechanisms. (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：41 / 44

页数：4