The pharmacology of CGRP-responsive receptors in cultured and transfected cells

被引：25

作者：

Hay, DL

Conner, AC

Howitt, SG

Takhshid, MA

Simms, J

Mahmoud, K

Poyner, DR ^{[1
]}

机构：

[1] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

[2] Univ Auckland, Liggins Inst, Auckland, New Zealand

[3] Univ Birmingham, Sch Biol Sci, Birmingham B15 2TT, W Midlands, England

[4] Shiraz Univ, Dept Biochem, Shiraz 71545, Iran

来源：

PEPTIDES | 2004年 / 25卷 / 11期

基金：

英国生物技术与生命科学研究理事会;

关键词：

CGRP; calcitonin receptor-like receptor; RAMP1; RAMP2; RAMP3; CL; CGRP(8-37); calcitonin receptor; BIBN4096BS;

D O I：

10.1016/j.peptides.2004.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however, this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor. (C) 2004 Elsevier Inc. All rights reserved.

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页码：2019 / 2026

页数：8

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