Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study

被引：56

作者：

Andersson, Charlotte ^{[1
,2
]}

Enserro, Danielle ^{[3
]}

Sullivan, Lisa ^{[3
]}

Wang, Thomas J. ^{[1
,2
,4
]}

Januzzi, James L., Jr. ^{[5
]}

Benjamin, Emelia J. ^{[1
,2
,6
,7
,8
]}

Vita, Joseph A. ^{[9
,10
]}

Hamburg, Naomi M. ^{[9
,10
]}

Larson, Martin G. ^{[1
,2
]}

Mitchell, Gary F. ^{[11
]}

Vasan, Ramachandran S. ^{[1
,2
,6
,7
,8
]}

机构：

[1] Boston Univ, Framingham Heart Study, Framingham, MA USA

[2] NHLBI, Framingham Heart Study, Framingham, MA USA

[3] Boston Univ, Dept Biostat, Framingham, MA USA

[4] Vanderbilt Univ, Div Cardiovasc Med, 221 Kirkland Hall, Nashville, TN 37235 USA

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA

[6] Boston Univ, Sch Med, Sect Prevent Med, Boston, MA 02118 USA

[7] Boston Univ, Sch Med, Cardiol Sect, Boston, MA 02118 USA

[8] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[9] Boston Univ, Sch Med, Evans Dept Med, Boston, MA 02118 USA

[10] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[11] Cardiovasc Engn Inc, Norwood, MA USA

来源：

ATHEROSCLEROSIS | 2016年 / 248卷

关键词：

Vascular stiffness; Endothelial function; Biomarkers; ST2; GDF-15; Troponin I; General population; GROWTH-DIFFERENTIATION FACTOR-15; FLOW-MEDIATED DILATION; ARTERIAL STIFFNESS; SYSTOLIC HYPERTENSION; AORTIC STIFFNESS; SENSITIVE ASSAY; PULSE PRESSURE; ASSOCIATION; MORTALITY; ATHEROSCLEROSIS;

D O I：

10.1016/j.atherosclerosis.2016.02.013

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s) ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 +/- 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007-0.081] standard deviation [SD] change per SD increase in log(e)[GDF-15], p = 0.02) and FW (0.076 [0.026-0.126] SD change per SD increase in log(e)[GDF-15], p = 0.003) and inversely related to FMD (-0.051 [-0.101-0.0003] SD change per SD increase in log(e)[GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005-0.063] SD change per SD increase in log(e)[sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (-0.041 [-0.082 -0.0004] SD change per SD increase in log(e)[hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：245 / 251

页数：7

共 30 条

[1]

GDF15, a cardioprotective TGF-β superfamily protein [J].

Ago, T ;

Sadoshima, J .

CIRCULATION RESEARCH, 2006, 98 (03) :294-297

[2]

Arterial stiffness is associated with minimally elevated high-sensitivity cardiac, troponin T levels in a community-dwelling population [J].

Bai, Yongyi ;

Ye, Ping ;

Luo, Leiming ;

Xiao, Wenkai ;

Xu, Ruyi ;

Wu, Hongmei ;

Bai, Jie .

ATHEROSCLEROSIS, 2011, 218 (02) :493-498

[3]

Clinical correlates and heritability of flow-mediated dilation in the community - The Framingham Heart Study [J].

Benjamin, EJ ;

Larson, MG ;

Keyes, MJ ;

Mitchell, GF ;

Vasan, RS ;

Keaney, JF ;

Lehman, BT ;

Fan, SX ;

Osypiuk, E ;

Vita, JA .

CIRCULATION, 2004, 109 (05) :613-619

[4]

Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production [J].

Choi, Yeon-Sook ;

Choi, Hyun-Jung ;

Min, Jeong-Ki ;

Pyun, Bo-Jeong ;

Maeng, Yong-Sun ;

Park, Hongryeol ;

Kim, Jihye ;

Kim, Young-Myeong ;

Kwon, Young-Guen .

BLOOD, 2009, 114 (14) :3117-3126

[5]

Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population [J].

de Lemos, James A. ;

Drazner, Mark H. ;

Omland, Torbjorn ;

Ayers, Colby R. ;

Khera, Amit ;

Rohatgi, Anand ;

Hashim, Ibrahim ;

Berry, Jarett D. ;

Das, Sandeep R. ;

Morrow, David A. ;

McGuire, Darren K. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (22) :2503-2512

[6]

Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults [J].

deFilippi, Christopher R. ;

de Lemos, James A. ;

Christenson, Robert H. ;

Gottdiener, John S. ;

Kop, Willem J. ;

Zhan, Min ;

Seliger, Stephen L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (22) :2494-2502

[7]

Soluble ST2 predicts elevated SBP in the community [J].

Ho, Jennifer E. ;

Larson, Martin G. ;

Ghorbani, Anahita ;

Cheng, Susan ;

Vasan, Ramachandran S. ;

Wang, Thomas J. ;

Januzzi, James L., Jr. .

JOURNAL OF HYPERTENSION, 2013, 31 (07) :1431-1436

[8]

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension [J].

Kaess, Bernhard M. ;

Rong, Jian ;

Larson, Martin G. ;

Hamburg, Naomi M. ;

Vita, Joseph A. ;

Levy, Daniel ;

Benjamin, Emelia J. ;

Vasan, Ramachandran S. ;

Mitchell, Gary F. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 308 (09) :875-881

[9]

The IL-33/ST2 pathway: therapeutic target and novel biomarker [J].

Kakkar, Rahul ;

Lee, Richard T. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (10) :827-840

[10]

Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function [J].

Kathiresan, S ;

Gona, P ;

Larson, MG ;

Vita, JA ;

Mitchell, GF ;

Tofler, GH ;

Levy, D ;

Newton-Cheh, C ;

Wang, TJ ;

Benjamin, EJ ;

Vasan, RS .

CIRCULATION, 2006, 113 (07) :938-945

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