Increase in the helper inducer (CD4+CD29+) T lymphocytes in smokers

被引：14

作者：

Tanigawa, T

Araki, S

Nakata, A

Sakurai, S

机构：

[1] Univ Tokyo, Fac Med, Dept Publ Hlth, Bunkyo Ku, Tokyo 113, Japan

[2] Tokyo Univ Hosp, Dept Cent Lab, Bunkyo Ku, Tokyo 113, Japan

来源：

INDUSTRIAL HEALTH | 1998年 / 36卷 / 01期

关键词：

smoking; CD4+CD29+ T lymphocytes; helper inducer T lymphocytes; T lymphocyte subpopulation; two color staining; flow cytometry; immune system;

D O I：

10.2486/indhealth.36.78

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Previously, we reported an increase in the number of CD4+ T lymphocytes in the peripheral blood of smokers, In the present study, subpopulations of CD4+ T lymphocytes together with CD8+ T lymphocytes, total (CD3+) T lymphocytes, B (CD19+) lymphocytes, natural killer (CD16+) cells and total lymphocytes were examined by two-color staining using anti-2H4 (CD45RA) and anti-4B4 (CD29) monoclonal antibodies in 8 male smokers and 22 age-matched male non-smokers, The number of CD4+CD29+ T lymphocytes in smokers was significantly higher than that in non-smokers. The total number of CD4+ T lymphocytes in smokers was also significantly higher, No significant differences in CD8+ T, CD19+ B lymphocytes and CD16+ NK cells were found between smokers and non-smokers, Thus, it is suggested that the increase in the number of CD4+CD29+ (helper inducer) T lymphocytes is responsible for the increase in total CD4+ T lymphocytes in smokers.

引用

页码：78 / 81

页数：4

共 15 条

[11] REVERSIBLE ALTERATIONS IN IMMUNOREGULATORY T-CELLS IN SMOKING - ANALYSIS BY MONOCLONAL-ANTIBODIES AND FLOW-CYTOMETRY [J].