Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations

被引：41

作者：

Kardia, SLR

Rozek, LS

Krushkal, J

Ferrell, RE

Turner, ST

Hutchinson, R

Brown, A

Sing, CF

Boerwinkle, E

机构：

[1] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[3] Worcester Polytech Inst, Dept Biol & Biotechnol, Worcester, MA 01609 USA

[4] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA

[5] Mayo Clin, Div Hypertens, Rochester, MN USA

[6] Univ Mississippi, Dept Med, Jackson, MS 39216 USA

[7] Univ Texas, Hlth Sci Ctr, Inst Mol Med, Houston, TX USA

[8] Univ Texas, Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2003年 / 16卷 / 02期

关键词：

linkage; hypertension; genetics;

D O I：

10.1016/S0895-7061(02)03249-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We report the results of a genome-wide linkage scan for hypertension genes in 450 African American hypertensive sibpairs from Jackson, MS, and 539 non-Hispanic white hypertensive sibpairs from Rochester, MN. In the Jackson samples we identified one LOD score peak > 1.0 on chromosome 1. In the Rochester sample, no genomic region had a LOD score > 1.0. These analyses provide no appreciable evidence of hypertension genes with strong effects independent of other genetic and environmental contexts and suggest that stratified linkage analyses may be required to identify hypertension susceptibility genes in these populations. (C) 2003 American Journal of Hypertension, Ltd.

引用

页码：154 / 157

页数：4

共 14 条

[1]

Black HR, 1997, ARCH INTERN MED, V157, P2413

[2] PREVALENCE OF HYPERTENSION IN THE US ADULT-POPULATION - RESULTS FROM THE 3RD NATIONAL-HEALTH AND NUTRITION EXAMINATION SURVEY, 1988-1991 [J].