Association of the mitochondrial DNA haplogroup J with longevity is population specific

被引：88

作者：

Dato, S

Passarino, G

Rose, G

Altomare, K

Bellizzi, D

Mari, V

Feraco, E

Franceschi, C

De Benedictis, G ^{[1
]}

机构：

[1] Univ Calabria, Dept Cell Biol, I-87036 Arcavacata Di Rende, Italy

[2] Italian Natl Res Ctr Aging, Cosenza, Italy

[3] Univ Bologna, Dept Mol Pathol, Bologna, Italy

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2004年 / 12卷 / 12期

关键词：

mtDNA; genetic variability; aging; longevity;

D O I：

10.1038/sj.ejhg.5201278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been reported to increase the individual chance to attain longevity in northern Italians, Northern Irish and Finns. However, since the genetic contribution to longevity may be population specific, we wanted to verify if haplogroup J does affect longevity also in a southern European population having a different genetic and environmental history. We analysed a population sample (883 subjects, 371 males and 521 females; age range 18-108 years) from southern Italy for the presence of haplogroup J. No frequency increase of this mtDNA haplogroup was found in the older cohorts, suggesting that, in this population, haplogroup J does not play a significant role in longevity. This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific.

引用

收藏

页码：1080 / 1082

页数：3

相关论文

共 12 条

[1] Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum [J].

Coskun, PE ;

Ruiz-Pesini, E ;

Wallace, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2174-2176

[2] Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans [J].

De Benedictis, G ;

Rose, G ;

Carrieri, G ;

De Luca, M ;

Falcone, E ;

Passarino, G ;

Bonafé, M ;

Monti, D ;

Baggio, G ;

Bertolini, S ;

Mari, D ;

Mattace, R ;

Franceschi, C .

FASEB JOURNAL, 1999, 13 (12) :1532-1536

[3] The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects [J].

Garasto, S ;

Rose, G ;

Derango, F ;

Berardelli, M ;

Corsonello, A ;

Feraco, E ;

Mari, V ;

Maletta, R ;

Bruni, A ;

Franceschi, C ;

Carotenuto, L ;

De Benedictis, G .

ANNALS OF HUMAN GENETICS, 2003, 67 :54-62

[4] Natural selection shaped regional mtDNA variation in humans [J].

Mishmar, D ;

Ruiz-Pesini, E ;

Golik, P ;

Macaulay, V ;

Clark, AG ;

Hosseini, S ;

Brandon, M ;

Easley, K ;

Chen, E ;

Brown, MD ;

Sukernik, RI ;

Olckers, A ;

Wallace, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :171-176

[5] Mitochondrial DNA polymorphisms associated with longevity in a Finnish population [J].

Niemi, AK ;

Hervonen, A ;

Hurme, M ;

Kurhunen, PJ ;

Jylhä, M ;

Majamaa, K .

HUMAN GENETICS, 2003, 112 (01) :29-33

[6] The variability of the mitochondrial genome in human aging: a key for life and death? [J].

Rose, G ;

Passarino, G ;

Franceschi, C ;

De Benedictis, G .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (11) :1449-1460

[7] Mitochondrial DNA polymorphism: its role in longevity of the Irish population [J].

Ross, OA ;

McCormack, R ;

Curran, MD ;

Duguid, RA ;

Barnett, YA ;

Rea, IM ;

Middleton, D .

EXPERIMENTAL GERONTOLOGY, 2001, 36 (07) :1161-1178

[8] Effects of purifying and adaptive selection on regional variation in human mtDNA [J].

Ruiz-Pesini, E ;

Mishmar, D ;

Brandon, M ;

Procaccio, V ;

Wallace, DC .

SCIENCE, 2004, 303 (5655) :223-226

[9]

SFORZA LLC, 1994, HIST GEOGRAPHY HUMAN, P277

[10] Mitochondrial genotype associated with longevity [J].

Tanaka, M ;

Gong, JS ;

Zhang, J ;

Yoneda, M ;

Yagi, K .

LANCET, 1998, 351 (9097) :185-186