Enantioselective 1,4-addition of aliphatic Grignard reagents to enones catalyzed by readily available copper(I) thiolates derived from TADDOL - Preliminary communication

被引：65

作者：

Seebach, D ^{[1
]}

Jaeschke, G ^{[1
]}

Pichota, A ^{[1
]}

Audergon, L ^{[1
]}

机构：

[1] ETH Zentrum, Organ Chem Lab, CH-8092 Zurich, Switzerland

来源：

HELVETICA CHIMICA ACTA | 1997年 / 80卷 / 08期

关键词：

D O I：

10.1002/hlca.19970800819

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two simple thiols derived from the parent TADDOL, alpha,alpha,alpha',alpha'-tetraphenyl-2,2-dimethyl-1,3-dioxolan-4,5-dimethanol, are used to prepare Cu-I complexes C and D to catalyze (0.05 equiv.) 1,4-additions of Grignard reagents RMgCl to cyclic enones with enantioselectivities which are comparable to or better than previously reported (enantiomer ratios up to 92:8).

引用

页码：2515 / 2519

页数：5

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