Involvement of α6β4 integrin in the mechanisms that regulate breast cancer progression

被引：46

作者：

Bon, Giulia ^{[1
]}

Folgiero, Valentina ^{[1
]}

Di Carlo, Selene ^{[1
]}

Sacchi, Ada ^{[1
]}

Falcioni, Rita ^{[1
]}

机构：

[1] Regina Elena Inst Canc Res, Dept Expt Oncol, Mol Oncogenesis Lab, I-00158 Rome, Italy

来源：

BREAST CANCER RESEARCH | 2007年 / 9卷 / 01期

关键词：

PHOSPHOINOSITIDE 3-OH KINASE; ALPHA-6-BETA-4; INTEGRIN; GENE-EXPRESSION; CARCINOMA CELLS; ACTIVATION; ADHESION; RECEPTOR; SURVIVAL; SUBUNIT; PROMOTE;

D O I：

10.1186/bcr1651

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrin alpha(6)beta(4) is mostly expressed in epithelial tissues and endothelial and Schwann cells. Expression of alpha(6)beta(4) is increased in many epithelial tumours, implicating its involvement in tumour malignancy. Moreover, this integrin activates several key signalling molecules in carcinoma cells, but its ability to activate the phosphatidylinositol 3-kinase/Akt pathway is among the mechanisms by which alpha(6)beta(4) integrin regulates tumour behaviour. In this review we discuss the biological and clinical features of alpha(6)beta(4) integrin that allow it to promote tumour survival and progression of mammary tumours.

引用

页数：5

共 47 条

[1] p53 inhibits α6β4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB [J].

Bachelder, RE ;

Ribick, MJ ;

Marchetti, A ;

Falcioni, R ;

Soddu, S ;

Davis, KR ;

Mercurio, AM .

JOURNAL OF CELL BIOLOGY, 1999, 147 (05) :1063-1072

[2]

BEROTTI A, 2005, CANCER RES, V65, P10674

[3] Loss of β4 integrin subunit reduces the tumorigenicity of MCF7 mammary cells and causes apoptosis upon hormone deprivation [J].

Bon, Giulia ;

Folgiero, Valentina ;

Bossi, Gianluca ;

Felicioni, Laura ;

Marchetti, Antonio ;

Sacchi, Ada ;

Falcioni, Rita .

CLINICAL CANCER RESEARCH, 2006, 12 (11) :3280-3287

[4] Hemidesmosomes: Roles in adhesion, signaling and human diseases [J].

Borradori, L ;

Sonnenberg, A .

CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (05) :647-656

[5]

CARTER BZ, 1991, LAB INVEST, V65, P610

[6]

Chao C, 1996, CANCER RES, V56, P4811

[7] Integrin α6β4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells [J].

Chen, M ;

O'Connor, KL .

ONCOGENE, 2005, 24 (32) :5125-5130

[8] Integrin (α6β4) regulation of eIF-4E activity and VEGF translation:: a survival mechanism for carcinoma cells [J].

Chung, J ;

Bachelder, RE ;

Lipscomb, EA ;

Shaw, LM ;

Mercurio, AM .

JOURNAL OF CELL BIOLOGY, 2002, 158 (01) :165-174

[9] β4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer [J].

Diaz, LK ;

Cristofanilli, M ;

Zhou, X ;

Welch, KL ;

Smith, TL ;

Yang, Y ;

Sneige, N ;

Sahin, AA ;

Gilcrease, MZ .

MODERN PATHOLOGY, 2005, 18 (09) :1165-1175

[10] Chromogenic in situ hybridization for α6β4 integrin in breast cancer correlation with protein expression [J].

Diaz, LK ;

Zhou, X ;

Welch, K ;

Sahin, A ;

Gilcrease, MZ .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2004, 6 (01) :10-15

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