Involvement of α6β4 integrin in the mechanisms that regulate breast cancer progression

被引：46

作者：

Bon, Giulia ^{[1
]}

Folgiero, Valentina ^{[1
]}

Di Carlo, Selene ^{[1
]}

Sacchi, Ada ^{[1
]}

Falcioni, Rita ^{[1
]}

机构：

[1] Regina Elena Inst Canc Res, Dept Expt Oncol, Mol Oncogenesis Lab, I-00158 Rome, Italy

来源：

BREAST CANCER RESEARCH | 2007年 / 9卷 / 01期

关键词：

PHOSPHOINOSITIDE 3-OH KINASE; ALPHA-6-BETA-4; INTEGRIN; GENE-EXPRESSION; CARCINOMA CELLS; ACTIVATION; ADHESION; RECEPTOR; SURVIVAL; SUBUNIT; PROMOTE;

D O I：

10.1186/bcr1651

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrin alpha(6)beta(4) is mostly expressed in epithelial tissues and endothelial and Schwann cells. Expression of alpha(6)beta(4) is increased in many epithelial tumours, implicating its involvement in tumour malignancy. Moreover, this integrin activates several key signalling molecules in carcinoma cells, but its ability to activate the phosphatidylinositol 3-kinase/Akt pathway is among the mechanisms by which alpha(6)beta(4) integrin regulates tumour behaviour. In this review we discuss the biological and clinical features of alpha(6)beta(4) integrin that allow it to promote tumour survival and progression of mammary tumours.

引用

页数：5

共 47 条

[41]

Tagliabue E, 1998, CLIN CANCER RES, V4, P407

[42] A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth [J].

Trusolino, L ;

Bertotti, A ;

Comoglio, PM .

CELL, 2001, 107 (05) :643-654

[43]

WATT FM, 1993, J CELL SCI, V106, P175

[44] Multiple functions of the integrin α6β4 in epidermal homeostasis and tumorigenesis [J].

Wilhelmsen, K ;

Litjens, SHM ;

Sonnenberg, A .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (08) :2877-2886

[45] Ras stimulation of E2F activity and a consequent E2F regulation of integrin α6β4 promote the invasion of breast carcinoma cells [J].

Yoon, Sang-Oh ;

Shin, Sejeong ;

Mercurio, Arthur M. .

CANCER RESEARCH, 2006, 66 (12) :6288-6295

[46] A novel mechanism for integrin-mediated Ras activation in breast carcinoma cells:: The α6β4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling [J].

Yoon, SO ;

Shin, S ;

Lipscomb, EA .

CANCER RESEARCH, 2006, 66 (05) :2732-2739

[47] Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the α6β4 integrin [J].

Yoon, SO ;

Shin, S ;

Mercurio, AM .

CANCER RESEARCH, 2005, 65 (07) :2761-2769

← 1 2 3 4 5 →