It could be habit forming: drugs of abuse and striatal synaptic plasticity

被引:357
作者
Gerdeman, GL [1 ]
Partridge, JG
Lupica, CR
Lovinger, DM
机构
[1] Univ Arizona, Hlth Sci Ctr, Dept Pharmacol, Tucson, AZ 85724 USA
[2] NIAAA, Lab Mol Physiol, Rockville, MD 20852 USA
[3] Div Intramural Clin & Basic Res, Rockville, MD 20852 USA
[4] NIDA, Sect Cellular Neurophysiol, Cellular Neurobiol Branch, Intramural Res Program, Baltimore, MD 21224 USA
[5] NIAAA, Lab Integrat Neurosci, Rockville, MD 20852 USA
关键词
D O I
10.1016/S0166-2236(03)00065-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Drug addiction can take control of the brain and behavior, activating behavioral patterns that are directed excessively and compulsively toward drug usage. Such patterns often involve the development of repetitive and nearly automatic behaviors that we call habits. The striatum, a subcortical brain region important for proper motor function as well as for the formation of behavioral habits, is a major target for drugs of abuse. Here, we review recent studies of long-term synaptic plasticity in the striatum, emphasizing that drugs of abuse can exert pronounced influences on these processes, both in the striatum and in the dopaminergic midbrain. Synaptic plasticity in the ventral striatum appears to play a prominent role in early stages of drug use, whereas dopamine- and endocannabinoid-dependent synaptic plasticity in the dorsal striatum could contribute to the formation of persistent drug-related habits when casual drug use progresses towards compulsive drug use and addiction.
引用
收藏
页码:184 / 192
页数:9
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