Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro

被引：35

作者：

Dimas, K

Demetzos, C ^{[1
]}

Angelopoulou, D

Kolokouris, A

Mavromoustakos, T

机构：

[1] Univ Athens, Sch Pharm, Dept Pharmacognosy, Athens, Greece

[2] Int Inst Anticanc Res, Athens, Greece

[3] Natl Hellen Res Fdn, Inst Organ & Pharmaceut Chem, Athens, Greece

来源：

PHARMACOLOGICAL RESEARCH | 2000年 / 42卷 / 05期

关键词：

Cistus monspeliensis (Cistaceae); myricetin derivatives; cytotoxic/cytostatic effect;

D O I：

10.1006/phrs.2000.0716

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two myricetin derivatives, the 3,7,4',5'-tetramethyl ether of myricetin (1), isolated from the hexane extract of Cistus monspeliensis, and its 3',5-diacetyl derivative (2) which was synthesized, and the parent compound, myricetin (3), were examined for their in vitro cytotoxic activity against nine human leukemic cell lines, two of which were mdr cell lines. Compound 2 exhibited higher cytostatic and cytotoxic activities in comparison to compound 1, while compound 3 was inactive against all tested cell lines. Vinblastine was used as a control. (C) 2000 Academic Press.

引用

页码：475 / 478

页数：4