Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

被引：4013

作者：

Kessenbrock, Kai ^{[1
,2
]}

Plaks, Vicki ^{[1
,2
]}

Werb, Zena ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Program Biomed Sci, San Francisco, CA 94143 USA

来源：

CELL | 2010年 / 141卷 / 01期

关键词：

SYNERGISTIC UP-REGULATION; EXTRACELLULAR-MATRIX; CELL-ADHESION; CANCER-CELLS; TGF-BETA; CHEMOKINE RECEPTOR; ENDOTHELIAL-CELLS; ANGIOGENIC SWITCH; BASEMENT-MEMBRANE; NECROSIS-FACTOR;

D O I：

10.1016/j.cell.2010.03.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis. The matrix metalloproteinases (MMPs) represent the most prominent family of proteinases associated with tumorigenesis. Recent technological developments have markedly advanced our understanding of MMPs as modulators of the tumor microenvironment. In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner. These aspects of MMP function are reorienting our approaches to cancer therapy.

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页码：52 / 67

页数：16

相关论文

共 132 条

[1] Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis [J].

Agrawal, S ;

Anderson, P ;

Durbeej, M ;

van Rooijen, N ;

Ivars, F ;

Opdenakker, G ;

Sorokin, LM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (04) :1007-1019

[2] Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells [J].

Ahn, G-One ;

Brown, J. Martin .

CANCER CELL, 2008, 13 (03) :193-205

[3] Stromelysin-1 regulates adipogenesis during mammary gland involution [J].

Alexander, CM ;

Selvarajan, S ;

Mudgett, J ;

Werb, Z .

JOURNAL OF CELL BIOLOGY, 2001, 152 (04) :693-703

[4] Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis [J].

Ardi, Veronica C. ;

Kupriyanova, Tatyana A. ;

Deryugina, Elena I. ;

Quigley, James P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (51) :20262-20267

[5] Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activation in Vivo and Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway [J].

Ardi, Veronica C. ;

Van den Steen, Philippe E. ;

Opdenakker, Ghislain ;

Schweighofer, Bernhard ;

Deryugina, Elena I. ;

Quigley, James P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (38) :25854-25866

[6] Loss of collagenase-2 confers increased skin tumor susceptibility to male mice [J].

Balbín, M ;

Fueyo, A ;

Tester, AM ;

Pendás, AM ;

Pitiot, AS ;

Astudillo, A ;

Overall, CM ;

Shapiro, SD ;

López-Otín, C .

NATURE GENETICS, 2003, 35 (03) :252-257

[7] Tumour necrosis factor and cancer [J].

Balkwill, Frances .

NATURE REVIEWS CANCER, 2009, 9 (05) :361-371

[8] Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].

Bergers, G ;

Brekken, R ;

McMahon, G ;

Vu, TH ;

Itoh, T ;

Tamaki, K ;

Tanzawa, K ;

Thorpe, P ;

Itohara, S ;

Werb, Z ;

Hanahan, D .

NATURE CELL BIOLOGY, 2000, 2 (10) :737-744

[9] Oncogenic pathway signatures in human cancers as a guide to targeted therapies [J].

Bild, AH ;

Yao, G ;

Chang, JT ;

Wang, QL ;

Potti, A ;

Chasse, D ;

Joshi, MB ;

Harpole, D ;

Lancaster, JM ;

Berchuck, A ;

Olson, JA ;

Marks, JR ;

Dressman, HK ;

West, M ;

Nevins, JR .

NATURE, 2006, 439 (7074) :353-357

[10] PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells [J].

Boire, A ;

Covic, L ;

Agarwal, A ;

Jacques, S ;

Sherifl, S ;

Kuliopulos, A .

CELL, 2005, 120 (03) :303-313

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