Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

被引：4013

作者：

Kessenbrock, Kai ^{[1
,2
]}

Plaks, Vicki ^{[1
,2
]}

Werb, Zena ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Program Biomed Sci, San Francisco, CA 94143 USA

来源：

CELL | 2010年 / 141卷 / 01期

关键词：

SYNERGISTIC UP-REGULATION; EXTRACELLULAR-MATRIX; CELL-ADHESION; CANCER-CELLS; TGF-BETA; CHEMOKINE RECEPTOR; ENDOTHELIAL-CELLS; ANGIOGENIC SWITCH; BASEMENT-MEMBRANE; NECROSIS-FACTOR;

D O I：

10.1016/j.cell.2010.03.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis. The matrix metalloproteinases (MMPs) represent the most prominent family of proteinases associated with tumorigenesis. Recent technological developments have markedly advanced our understanding of MMPs as modulators of the tumor microenvironment. In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner. These aspects of MMP function are reorienting our approaches to cancer therapy.

引用

页码：52 / 67

页数：16

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