Relatively few deep, stratified, multicomponent Paleoindian sites have been found in alluvial contexts in North America. Recent excavations at the Big Eddy site in southwest Missouri, however, reveal the presence of unique, stratified Paleoindian horizons containing Clovis, Dalton, and San Patrice components. Limited excavations below the Clovis stratum also provide strong evidence for the presence of one or more pre-Clovis horizons. Results of the work at Big Eddy, including discussions of geomorphic contexts, prehistoric components, features, artifacts, and radiocarbon assays, are provided.