Epithelial lineages of the small intestine have unique patterns of GATA expression

被引:25
作者
Dusing, MR
Wiginton, DA [1 ]
机构
[1] Univ Cincinnati, Coll Med, Dept Pediat, Div Dev Biol, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Res Fdn, Cincinnati, OH 45229 USA
关键词
D O I
10.1007/s10735-004-2908-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The ability of the GATA family of factors to interact with numerous other factors, co-factors, and repressors suggests that they may play key roles in tissues and cells where they are expressed. Adult mouse small intestine has been shown to express GATA-4, GATA-5, and GATA-6, where they have been implicated in the activation of a number of intestinal genes. Determination of which GATA factor(s) are involved in a specific function in tissues expressing multiple family members has proven difficult. The immunohistochemical analysis presented here demonstrate that within the mouse small intestine GATA-4/-5/-6 are found to be uniquely distributed among the various differentiated lineages of the intestinal epithelium. Among differentiated cells GATA-4 is found only in the villous enterocytes. GATA-5 is absent from enterocytes, but was found in the remaining lineages: goblet, Paneth and enteroendocrine. Additionally, high levels of GATA-6 are found in only one of these differentiated cell types, the enteroendocrine lineage. The observed distribution suggests that the GATA factors may have distinct roles in lineage allocation, lineage maintenance, and/or terminal differentiation events in small intestine.
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收藏
页码:15 / 24
页数:10
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