Cellular mechanisms of T cell mediated drug hypersensitivity

被引：34

作者：

Gerber, BO ^{[1
]}

Pichler, WJ ^{[1
]}

机构：

[1] Inselspital Bern, Clin Rheumatol & Clin Immunol Allergol, Div Allergol, CH-3010 Bern, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.coi.2004.09.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.

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收藏

页码：732 / 737

页数：6

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