Cellular mechanisms of T cell mediated drug hypersensitivity

被引：34

作者：

Gerber, BO ^{[1
]}

Pichler, WJ ^{[1
]}

机构：

[1] Inselspital Bern, Clin Rheumatol & Clin Immunol Allergol, Div Allergol, CH-3010 Bern, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.coi.2004.09.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.

引用

页码：732 / 737

页数：6

共 42 条

[11] A new type of metal recognition by human T cells: Contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel [J].

Gamerdinger, K ;

Moulon, C ;

Karp, DR ;

van Bergen, J ;

Koning, F ;

Wild, D ;

Pflugfelder, U ;

Weltzien, HU .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (10) :1345-1353

[12] Allergic and autoimmune reactions to xenobiotics:: how do they arise? [J].

Griem, P ;

Wulferink, M ;

Sachs, B ;

González, JB ;

Gleichmann, E .

IMMUNOLOGY TODAY, 1998, 19 (03) :133-141

[13] T cell involvement in cutaneous drug eruptions [J].

Hari, Y ;

Frutig-Schnyder, K ;

Hurni, M ;

Yawalkar, N ;

Zanni, MP ;

Schnyder, B ;

Kappeler, A ;

Von Greyerz, S ;

Braathen, LR ;

Pichler, WJ .

CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (09) :1398-1408

[14] Idiosyncratic drug reactions: the reactive metabolite syndromes [J].

Knowles, SR ;

Uetrecht, J ;

Shear, NH .

LANCET, 2000, 356 (9241) :1587-1591

[15] Components of the ligand for a Ni++ reactive human T cell clone [J].

Lu, L ;

Vollmer, J ;

Moulon, C ;

Weltzien, HU ;

Marrack, P ;

Kappler, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) :567-574

[16] Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir [J].

Mallal, S ;

Nolan, D ;

Witt, C ;

Masel, G ;

Martin, AM ;

Moore, C ;

Sayer, D ;

Castley, A ;

Mamotte, C ;

Maxwell, D ;

James, I ;

Christiansen, FT .

LANCET, 2002, 359 (9308) :727-732

[17] Detection of specific IgE to quinolones [J].

Manfredi, M ;

Severino, M ;

Testi, S ;

Macchia, D ;

Ermini, G ;

Pichler, WJ ;

Campi, P .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (01) :155-160

[18]

MauriHellweg D, 1996, J IMMUNOL, V157, P1071

[19] Characterization of drug-specific T cells in lamotrigine hypersensitivity [J].

Naisbitt, DJ ;

Farrell, J ;

Wong, G ;

Depta, JPH ;

Dodd, CC ;

Hopkins, JE ;

Gibney, CA ;

Chadwick, DW ;

Pickler, WJ ;

Pirmohamed, M ;

Park, BK .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (06) :1393-1403

[20] Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones [J].

Naisbitt, DJ ;

Britschgi, M ;