Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blood monocytes

被引:68
作者
Kubo, A
Minamino, N
Isumi, Y
Kangawa, K
Dohi, K
Matsuo, H
机构
[1] Natl Cardiovasc Ctr, Res Inst, Suita, Osaka 5658565, Japan
[2] Nara Med Univ, Dept Internal Med 1, Kashihara, Nara 6340813, Japan
基金
日本科学技术振兴机构;
关键词
adrenomedullin; monocyte; macrophage; granulocyte; differentiation;
D O I
10.1016/S0014-5793(98)00349-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We demonstrated that adrenomedullin (ARI) is produced and secreted from human leukemia cell lines (THP-I and HL-60) as well as peripheral blood granulocytes, lymphocytes , monocytes and monocyte-derived macrophages, Immunoreactive ARI accumulated in the culture media of THP-1 and HL-60 cells increased according to their differentiation into macrophage-like cells. Retinoic acid exerted synergistic effects on AM secretion from THP-1 and HL-60 cells when administered with tumor necrosis factor-alpha, lipopolysaccharide or 12-O-tetradecanoyl phorbol-13-acetate, AM was shown to increase the scavenger receptor activity on THP-1 cells. Thus, monocytes/macrophages should be recognized as sources of AM, and the secreted AM may modulate the function of macrophages, (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码:233 / 237
页数:5
相关论文
共 28 条
[1]   SUSTAINED ACTIVATION OF PROTEIN-KINASE-C IS ESSENTIAL TO HL-60 CELL-DIFFERENTIATION TO MACROPHAGE [J].
AIHARA, H ;
ASAOKA, Y ;
YOSHIDA, K ;
NISHIZUKA, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11062-11066
[2]  
AKESON AL, 1991, J LIPID RES, V32, P1699
[3]   THE HUMAN LEUKEMIA-CELL LINE, THP-1 - A MULTIFACETED MODEL FOR THE STUDY OF MONOCYTE-MACROPHAGE DIFFERENTIATION [J].
AUWERX, J .
EXPERIENTIA, 1991, 47 (01) :22-31
[4]   RETINOIC ACID INDUCES INTERCELLULAR-ADHESION MOLECULE-1 HYPEREXPRESSION IN HUMAN THYROID-CARCINOMA CELL-LINES [J].
BASSI, V ;
VITALE, M ;
FELICIELLO, A ;
DERIU, S ;
ROSSI, G ;
FENZI, G .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (04) :1129-1135
[5]   Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D [J].
Brown, TRP ;
Stonehouse, TJ ;
Branch, JS ;
Brickell, PM ;
Katz, DR .
EXPERIMENTAL CELL RESEARCH, 1997, 236 (01) :94-102
[6]  
CHAMBAUTGUERIN AM, 1995, J NEUROCHEM, V65, P537
[7]   EFFECTS OF RETINOIDS ON MACROPHAGE FUNCTION AND IL-1 ACTIVITY [J].
DILLEHAY, DL ;
WALIA, AS ;
LAMON, EW .
JOURNAL OF LEUKOCYTE BIOLOGY, 1988, 44 (05) :353-360
[8]  
GANDE A, 1995, EXP HEMATOL, V23, P117
[9]   RECOGNITION AND PLASMA-CLEARANCE OF ENDOTOXIN BY SCAVENGER RECEPTORS [J].
HAMPTON, RY ;
GOLENBOCK, DT ;
PENMAN, M ;
KRIEGER, M ;
RAETZ, CRH .
NATURE, 1991, 352 (6333) :342-344
[10]   DEXAMETHASONE AND PENTOXIFYLLINE INHIBIT ENDOTOXIN-INDUCED CACHECTIN TUMOR-NECROSIS-FACTOR SYNTHESIS AT SEPARATE POINTS IN THE SIGNALING PATHWAY [J].
HAN, J ;
THOMPSON, P ;
BEUTLER, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :391-394