Protein nanostructures formed via direct-write dip-pen nanolithography

被引：285

作者：

Lee, KB

Lim, JH

Mirkin, CA

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Inst Nanotechnol, Evanston, IL 60208 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 19期

关键词：

D O I：

10.1021/ja034236p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a tip modification strategy coupled with dip-pen nanolithography for depositing proteins on a surface. This methodology offers patterning capabilities on the scale of 45 nm to many micrometers length. The biorecognition properties of nanofeatures composed of immunoglobulin-gamma (IgG) were confirmed by reacting the array with gold nanoparticles coated with anti-IgG. Furthermore, a two component nanoarray was fabricated in direct-write fashion by DPN, and the biorecognition properties of this structure were investigated by AFM without biodiagnostic labels. Copyright © 2003 American Chemical Society.

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页码：5588 / 5589

页数：2

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