共 21 条
Protein nanostructures formed via direct-write dip-pen nanolithography
被引:285
作者:
Lee, KB
Lim, JH
Mirkin, CA
机构:
[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[2] Northwestern Univ, Inst Nanotechnol, Evanston, IL 60208 USA
关键词:
D O I:
10.1021/ja034236p
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
We report a tip modification strategy coupled with dip-pen nanolithography for depositing proteins on a surface. This methodology offers patterning capabilities on the scale of 45 nm to many micrometers length. The biorecognition properties of nanofeatures composed of immunoglobulin-gamma (IgG) were confirmed by reacting the array with gold nanoparticles coated with anti-IgG. Furthermore, a two component nanoarray was fabricated in direct-write fashion by DPN, and the biorecognition properties of this structure were investigated by AFM without biodiagnostic labels. Copyright © 2003 American Chemical Society.
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页码:5588 / 5589
页数:2
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