The inhibition of long-term potentiation in the rat dentate gyrus by pro-inflammatory cytokines is attenuated in the presence of nicotine

被引：31

作者：

Curran, BP ^{[1
]}

O'Connor, JJ ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Human Anat & Physiol, Dublin 2, Ireland

来源：

NEUROSCIENCE LETTERS | 2003年 / 344卷 / 02期

关键词：

nicotine; long-term potentiation; interleukin; 1; beta; interleukin-18; tumour necrosis factor-alpha; depotentiation; hippocampus;

D O I：

10.1016/S0304-3940(03)00440-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nicotine has previously been shown to affect both long-term potentiation (LTP) and long-term. depression and to reverse age-related impairments of LTP in the hippocampus. Levels of proinflammatory cytokines are known to be elevated with age and to inhibit LTP. In the present study we have investigated the effects of three pro-inflammatory cytokines on nicotine-enhanced LTP in the rat hippocampus in vitro. In the presence of nicotine the inhibitory effect of interleukin-1beta, interleukin-18 and tumour necrosis factor-alpha on LTP was eliminated. Furthermore, significant depotentiation of established LTP could not be obtained in slices treated with nicotine. These experiments demonstrate that nicotine can reverse the inhibitory effects of pro-inflammatory cytokines on LTP. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 106

页数：4

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