Beckmann reaction of oximes catalysed by chloral: mild and neutral procedures

被引：72

作者：

Chandrasekhar, S ^{[1
]}

Gopalaiah, K ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 04期

关键词：

Beckmann rearrangement; catalytic; chloral; environmentally mild;

D O I：

10.1016/S0040-4039(02)02644-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of ketoximes undergo the Beckmann rearrangement when heated with 0.5 molar equiv. of chloral (neat melt/ similar to 130degreesC), to furnish the corresponding amides in excellent yields (generally 80-95%) after simple work-up. (Aromatic aldoximes dehydrated to the corresponding nitriles in excellent yields under similar conditions.) The absence of solvent, Bronsted acids, strong Lewis acids and by-products, and a simple work-up characterise the procedures. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：755 / 756

页数：2