Protective immunity against HSV-2 in the mouse vagina

被引：29

作者：

Parr, MB ^{[1
]}

Parr, EL ^{[1
]}

机构：

[1] So Illinois Univ, Dept Anat, Carbondale, IL 62901 USA

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1997年 / 36卷 / 1-2期

关键词：

herpes simplex virus; immunoglobulin G (IgG); mucosal immunity; secretory immunoglobulin A (S-IgA); T cell immunity; vagina;

D O I：

10.1016/S0165-0378(97)00055-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. The high prevalence of HSV-2 in humans underscores the need to develop an effective vaccine. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by a better understanding of the immune mechanisms that protect the female reproductive tract against infections in animal models. Such information would be invaluable in developing vaccine strategies to promote the type and magnitude of immune responses in the genital tract that would effectively protect against infection. This review focuses on recent studies using a progestin-treated adult mouse model to explore mucosal immunity to HSV-2 in the vagina. Evidence indicating a major role for both humoral and T cell immunity is presented. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：77 / 92

页数：16

共 71 条

[11] Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of Hsai-Labile enterotoxin as a mucosal adjuvant [J].