Are Acute Infarcts the Cause of Leukoaraiosis? Brain Mapping for 16 Consecutive Weeks

被引：81

作者：

Conklin, John ^{[1
]}

Silver, Frank L. ^{[2
,3
]}

Mikulis, David J. ^{[1
,4
]}

Mandell, Daniel M. ^{[1
,4
]}

机构：

[1] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[2] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[3] Univ Hlth Network, Toronto, ON, Canada

[4] Univ Hlth Network, Dept Med Imaging, Div Neuroradiol, Toronto, ON, Canada

来源：

ANNALS OF NEUROLOGY | 2014年 / 76卷 / 06期

关键词：

APPARENT DIFFUSION-COEFFICIENT; WHITE-MATTER HYPERINTENSITIES; SMALL VESSEL DISEASE; LACUNAR INFARCTS; LESIONS; BURDEN; STROKE; PROGRESSION; PREDICTORS; EVOLUTION;

D O I：

10.1002/ana.24285

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Neuroimaging of older adults commonly reveals abnormality (leukoaraiosis) in the cerebral white matter. Studies have established that extensive leukoaraiosis predicts dementia and disability, but the pathogenesis of leukoaraiosis remains unclear. We recruited 5 patients with leukoaraiosis and performed magnetic resonance mapping of the brain for 16 consecutive weeks. We observed tiny lesions arising de novo in the cerebral white matter. These lesions were clinically silent. They had the signature features of acute ischemic stroke. With time, the characteristics of these lesions approached those of pre-existing leukoaraiosis. Together, these findings suggest that tiny silent acute infarcts are a cause of leukoaraiosis. Ann Neurol 2014;76:899-904

引用

页码：899 / 904

页数：6

共 35 条

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Incidental Magnetic Resonance Diffusion-Weighted Imaging-Positive Lesions Are Rare in Neurologically Asymptomatic Community-Dwelling Adults [J].