p16INK4a as a tumor suppressor with therapeutic applicability

被引：2

作者：

Calbó, J ^{[1
]}

Mazo, A ^{[1
]}

机构：

[1] Univ Barcelona, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain

来源：

DRUGS OF THE FUTURE | 2003年 / 28卷 / 02期

关键词：

D O I：

10.1358/dof.2003.028.02.856928

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The p16(INK4a/ARF) locus encodes for 2 tumor suppressor genes commonly lost during transformation and acquisition of malignancy processes. The product of p16(INK4a) gene is a CDK inhibitor that constrains cell cycle progression in response to different proliferative stresses and participates in cell-environment signaling pathways. Restitution of p16/(INK4a) function has showed potent antitumoral activity in new gene therapy approaches and should be taken into consideration for future design of rationale and specific therapeutic strategies against cancer.

引用

页码：153 / 166

页数：14

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