Neuronal diversification: development of motor neuron subtypes

被引：73

作者：

Pfaff, S

Kintner, C

机构：

[1] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(98)80005-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent progress has been made in defining the developmental mechanisms that contribute to the diversification of motor neuron subtypes, which differ in transcription factor gene expression and synaptic connections. These studies suggest that progenitor cells acquire specific motor neuron identities through the coordinate actions of multiple factors. Current evidence suggests that Sonic hedgehog initiates a common pathway for motor neuron differentiation, while positionally distributed factors act to assign subtype identities.

引用

页码：27 / 36

页数：10