Notch signal transduction: a real Rip and more

被引：159

作者：

Weinmaster, G ^{[1
]}

机构：

[1] Univ Calif Los Angeles, UCLA Sch Med, Dept Biol Chem, Ctr Hlth Sci 33 257, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(00)00097-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.

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收藏

页码：363 / 369

页数：7

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