Selective lithiation of 4-(1H-1-pyrrolyl)pyridine.: Access to new electron-releasing ligands

被引：31

作者：

Martineau, D ^{[1
]}

Gros, P ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Henri Poincare, CNRS, UMR 7565, Synth Organomet & React, F-54506 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 23期

关键词：

D O I：

10.1021/jo0496244

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first lithiation of 4-(1H-1-pyrr0lYl)pyridine has been realized. The use of BuLi-containing lithium aggregates induced the selective pyridine ring functionalization by taking advantage of the electrondonor effect of the pyrrole nucleus. Opportune substituents were introduced oc to the pyridine nitrogen leading to new electron-enriched pyridylphosphine, bipyridine, and terpyridine ligands.

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页码：7914 / 7918

页数：5

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