Molecular recognition drives oligonucleotide binding to nucleolipid self-assemblies

被引：49

作者：

Banchelli, Martina

Berti, Debora

Baglioni, Piero

机构：

[1] Univ Florence, Dipartimento Chim, I-50019 Sesto Fiorentino, Firenze, Italy

[2] CSGI, I-50019 Sesto Fiorentino, Firenze, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 17期

关键词：

DNA; lipids; micelles; molecular recognition; self-assembly;

D O I：

10.1002/anie.200604826

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Ordered interactions: Selective supramolecular association of oligonucleotides with like-charged amphiphilic self-assemblies in aqueous solution, in the absence of divalent cations, is reported. A structural model of the nucleolipoplex, the ordered mesophase formed upon interaction of DNA (red) with anionic nucleolipid assemblies (green), is shown. The hexagonal arrangement is templated by the complementary polynucleotide. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3070 / 3073

页数：4

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