Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression

被引：92

作者：

Wang, CF

Billington, CJ

Levine, AS

Kotz, CM

机构：

[1] Vet Affairs Med Ctr, Res Serv 151, Minneapolis, MN 55417 USA

[2] Minnesota Obes Ctr, Minneapolis, MN 55417 USA

[3] Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN 55108 USA

[4] Univ Minnesota, Dept Psychiat, St Paul, MN 55108 USA

[5] Univ Minnesota, Dept Med, St Paul, MN 55108 USA

来源：

NEUROREPORT | 2000年 / 11卷 / 14期

关键词：

CART; feeding behavior; PVN; uncoupling protein;

D O I：

10.1097/00001756-200009280-00040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cocaine and amphetamine regulated transcript (CART) decreases feeding and body weight after ventricular injection. CART mRNA and peptide are found in the paraventricular nucleus of the hypothalamus (PVN). The purpose of the present study was to determine effects of PVN-injected CART on feeding and thermogenic capacity. PVN-injected CART (55-102, 100 pmol) significantly decreased NPY-induced feeding at 1, 2 and 4 h, but did not significantly affect deprivation-induced feeding. CART induced gene expression of uncoupling protein 1 (UCP1), UCP2, and UCP3 in brown and white adipose tissue and biceps femoris muscle respectively. These results indicate the PVN as a specific site of CART action, and suggest that CART in the PVN may have an important influence on energy metabolism. NeuroReport 11:3251-3255 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3251 / 3255

页数：5

共 31 条

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