Cholecystokinin modulates the aversive component of morphine withdrawal syndrome in rats

被引:17
作者
Valverde, O [1 ]
Roques, BP [1 ]
机构
[1] UFR Sci Pharmaceut & Biol, CNRS, URA D 1500, INSERM,U266,Dept Pharmaccochim Mol & Struct, F-75270 Paris 06, France
关键词
cholecystokinin; CCKB antagonist; conditioned place aversion; morphine dependence; PD-134,308; L-365,260; devazepide; BC; 264;
D O I
10.1016/S0304-3940(98)00118-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The conditioned place aversion paradigm was used to investigate the role of cholecystokinin in the aversive/dysphoric component of morphine abstinence. Several cholecystokinin ligands were chronically administered during the development of morphine dependence: the CCKA antagonist devazepide, the CCKB antagonists PD-134,308 and L-365,260, and the CCKB agonist BC 264. The CCK-B antagonists L-365,260 and PD-134,308 decreased and completely blocked (respectively) the place aversion induced by naloxone in morphine dependent animals whereas BC 264 and devazepide were inactive in this model. No effect was observed in non-dependent animals after chronic administration of these CCK-ligands. These results show a distinct role for CCK receptors in the regulation of the motivational component of morphine abstinence, probably related to their differential effects in the regulation of limbic dopaminergic neurons. (C) 1998 Published by Elsevier Science ireland Ltd.
引用
收藏
页码:37 / 40
页数:4
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