IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: preliminary findings

被引：17

作者：

Gelati, M

Lamperti, E

Dufour, A

Corsini, E

Venegoni, E

Milanese, C

Nespolo, A

Salmaggi, A

机构：

[1] IST NAZL NEUROL C BESTA,I-20133 MILAN,ITALY

[2] PRESIDIO OSPED MAGENTA,AZIENDA USSL 35,SERV NEUROL MED 1,MAGENTA,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1997年 / 18卷 / 04期

关键词：

IL-10; SM; SLE; steroids;

D O I：

10.1007/BF02080463

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA-stimulated PBMNCs from MS patients produced large amounts of the cytokine.

引用

收藏

页码：191 / 194

页数：4

相关论文

共 12 条

[1]

ALTERATIONS IN PERIPHERAL-BLOOD MONONUCLEAR CELL CYTOKINE PRODUCTION IN RESPONSE TO PHYTOHEMAGGLUTININ IN MULTIPLE-SCLEROSIS PATIENTS [J].

CRUCIAN, B ;

DUNNE, P ;

FRIEDMAN, H ;

RAGSDALE, R ;

PROSS, S ;

WIDEN, R .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1995, 2 (06) :766-769

[2]

FIORENTINO DF, 1991, J IMMUNOL, V147, P3815

[3]

INTRATHECAL SYNTHESIS OF INTERLEUKIN-10 (IL-10) IN VIRAL AND INFLAMMATORY DISEASES OF THE CENTRAL-NERVOUS-SYSTEM [J].

GALLO, P ;

SIVIERI, S ;

RINALDI, L ;

YAN, XB ;

LOLLI, F ;

DEROSSI, A ;

TAVOLATO, B .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1994, 126 (01) :49-53

[4]

HOSSIAU FA, 1995, LUPUS, V4, P393

[5]

HUANG YP, 1988, J IMMUNOL, V141, P827

[6]

ROLE OF INTERLEUKIN-10 IN THE B-LYMPHOCYTE HYPERACTIVITY AND AUTOANTIBODY PRODUCTION OF HUMAN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

LLORENTE, L ;

ZOU, WP ;

LEVY, Y ;

RICHAUDPATIN, Y ;

WIJDENES, J ;

ALCOCERVARELA, J ;

MORELFOURRIER, B ;

BROUET, JC ;

ALARCONSEGOVIA, D ;

GALANAUD, P ;

EMILIE, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (03) :839-844

[7]

IN-VIVO PRODUCTION OF INTERLEUKIN-10 BY NON-T CELLS IN RHEUMATOID-ARTHRITIS, SJOGRENS-SYNDROME, AND SYSTEMIC LUPUS-ERYTHEMATOSUS - A POTENTIAL MECHANISM OF B-LYMPHOCYTE HYPERACTIVITY AND AUTOIMMUNITY [J].

LLORENTE, L ;

RICHAUDPATIN, Y ;

FIOR, R ;

ALCOCERVARELA, J ;

WIJDENES, J ;

FOURRIER, BM ;

GALANAUD, P ;

EMILIE, D .

ARTHRITIS AND RHEUMATISM, 1994, 37 (11) :1647-1655

[8]

MURAKAWA Y, 1985, J IMMUNOL, V134, P187

[9]

INTERLEUKIN-10 PREVENTS EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS [J].

ROTT, O ;

FLEISCHER, B ;

CASH, E .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (06) :1434-1440

[10]

INTERLEUKIN-10 IS A POTENT GROWTH AND DIFFERENTIATION FACTOR FOR ACTIVATED HUMAN LYMPHOCYTES-B [J].

ROUSSET, F ;

GARCIA, E ;

DEFRANCE, T ;

PERONNE, C ;

VEZZIO, N ;

HSU, DH ;

KASTELEIN, R ;

MOORE, KW ;

BANCHEREAU, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1890-1893